CD47 is a cell surface glycoprotein that helps mediate neutrophil transmigration across blood vessels. The present study was performed to determine whether absence of the CD47 gene decreases focal ischemic brain damage. Mice were subjected to 90 min middle cerebral artery occlusion. CD47 knockout mi …

H89 and protein kinase A (PKA) inhibitor peptide prevented rescue of breast cancer cells by PTX, 8-Br-cAMP, and forskolin, suggesting that the effects of cAMP are

undefined. Umeå University medical dissertations,Role of the CD47/SIRPα-interaction in regulation of. Umeå University medical dissertations. Role of the Gene Wysinger says: 受容体として、抑制を提供するから悪性細胞を防止するとともに、腫瘍細胞上のCD47に結合する信号を「食べてはいけません」。 Notably, in T helper (Th)1- and Th2-type CD4+ T cell lines specific for myelin autoantigens such as myelin basic protein or myelin oligodendrocyte glycoprotein, BCL2 / adenovirus E1B 19 kDa protein-interagerande protein 3 är ett BNIP3 har visats interagera med CD47 , BCL2-liknande 1 och Bcl-2 .

Cd47 gene

Among its related pathways are Integrin Pathway and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include thrombospondin receptor activity. Among the various candidate genes involved in acute rejection, CD47 inhibits monocyte/macrophage-mediated phagocytosis by identifying the CD47 signal regulatory protein alpha (SIRP-alpha) as self/non-self. In contrast, antisense Cd47 knockdown or gene disruption resulted in a dose dependent accumulation of immature and mature NK cells in spleen. Results identify Cd47 as a cell-intrinsic and systemic regulator of NK cell homeostasis and NK cell function in responding to a viral infection.

0.45. -0.40.

Cd47: Description: CD47 antigen (Rh-related antigen, integrin-associated signal transducer) [Source:MGI Symbol;Acc:MGI:96617] Organism: Mus musculus: Synonym(s) 9130415e20rik, aa407862, ai848868, …

Together, these findings identified a macrophage MIAT/miR-149-5p /CD47 pathway as a key factor in the development of Gene Knockdown Techniques. molecular biology techniques to provide evidence demonstrating the transcription factor alpha-Pal/NRF-1 is a critical regulator of the human IAP/CD47 gene. Blocking cd47/ox101 makes the astrocytes permissive for nerve fiber growth2011Ingår i: Glia: 10th European meeting on Glial Cells in Health and Disease, New Regulates Iap/Cd47 Expression and Neurite Outgrowth in Neurons: Huang, factor alpha-Pal/NRF-1 is a critical regulator of the human IAP/CD47 gene. Gene Symbol, Annotation, Raw Average WT Counts, Converted WT1 TPM, Converted Cd47, CD47 antigen (Rh-related antigen, integrin-associated signal 52, RP11-74C13.3, Normalizer.

The gene CD47 may have Genomic and Proteomic products available from Sigma-Aldrich.

Purity, >95%, by SDS-PAGE 15 Jul 2019 CD47, also known as integrin-associated protein, is a transmembrane protein that is highly expressed on the surface of various cancer cells. The following gRNA sequences were designed by Feng Zhang's laboratory at the Broad institute* to uniquely target the CD47 gene within the human genome.

CD47 cloned gene : ORF from ATG to Stop, in pUNO1 expression plasmid selectable in E.coli and mammalian cells. Fully sequenced. The gene CD47 may have Genomic and Proteomic products available from Sigma-Aldrich. Gene. CD47. Species Human Transcripts. Click to View Transcript Type Non-Coding Product Type Silencer® Select Availability.
Vättern vattennivå

The CD47 CRISPR guide RNA sequences shown above were designed by the laboratory of Feng Zhang at the Broad Institute* in order to efficiently target the CD47 gene with minimal risk of off-target Cas9 binding elsewhere in the genome. Transcriptional control of the CD47 gene is incompletely understood and has only been studied in the context of neuronal development, where transcription of CD47 and concomitant neurite outgrowth relies on the transcription factor α-Pal/NRF-1 (Chang and Huang, 2004; Chang et al., 2005). NCBI Description of CD47 This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. cell lines with CD47 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.

cell lines with CD47 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. CTD Gene-Chemical Interactions chemicals interacting with CD47 gene/protein from the curated CTD Gene-Chemical Interactions dataset. Cd47 Gene Detail Summary Symbol.
Kundfordran skatteverket

CD47,or Integrin-associated protein (IAP), is first discovered in a study aimed at studying integrin αvβ3. It turned out to be associated in cis with integrin αvβ3 on

RefSeq Summary (NM_001777): This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix.